HUMAN IgG SUBCLASS LIQUID REAGENT KITS

In normal adults, IgG constitutes approximately 75% of the total serum immunoglobulins. Within the IgG class, the usual order of concentration of the 4 subclasses is IgG1> IgG2> IgG3> IgG4, but the actual concentration of each may vary markedly between individuals. The four IgG subclasses show considerable differences in their properties, including ability to fix complement, to bind to macrophages and to pass through the placenta. Abnormal levels of one or more subclasses may be associated with certain conditions, including anaphylaxis, autoimmune and gut diseases as well as hypoand hypergammaglobulinaemia (ref 1). In particular, reduced production of IgG2 in children may be associated with recurrent infections (ref 2). The subject has been reviewed (refs 3, 4 and 5). Roche turbidimetric analysers permit fully automatic, rapid quantitative measurement of precipitation reactions for protein determination and can run IgG1-4 assays concurrently.